Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701753 | 1.00 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL7576836 | 0.88 | HTR2C (0.37) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL3295186 | 0.80 | HTR2C (0.40) | NPC1RAB9ASMN1; SMN2HTR2CMEN1 | |
| SCHEMBL8699834 | 0.80 | HTR2C (0.40) | NPC1RAB9ASMN1; SMN2HTR2CMEN1 | |
| SCHEMBL18813753 | 0.74 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL18813754 | 0.74 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL2435139 | 0.72 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HTR2CMEN1 | |
| SCHEMBL2430964 | 0.70 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2HTR2CMEN1 | |
| SCHEMBL13378597 | 0.69 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL19635980 | 0.68 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760029-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |