Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8699834 | 1.00 | HTR2C (0.40) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL8701753 | 0.80 | NPC1 (0.42) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL8701759 | 0.80 | NPC1 (0.42) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL7576836 | 0.79 | HTR2C (0.37) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL4698979 | 0.78 | NR1H2 (0.36) | — | |
| SCHEMBL2502213 | 0.75 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2146179 | 0.75 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL18340933 | 0.75 | HTR2C (0.46) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5491000 | 0.74 | SMN1; SMN2 (0.43) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2435139 | 0.73 | SMN1; SMN2 (0.46) | HTR2CPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2839860-B1 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LTD (GB) | 2019-05-01 | — | — | EP | disclosed |
| EP-2839860-A1 | Pyrrolobenzodiazepines and conjugates thereof | Spirogen Sàrl (CH) | 2015-02-25 | — | — | EP | disclosed |
| US-8633185-B2 | Pyrrolobenzodiazepines | SPIROGEN SARL (CH) | 2014-01-21 | — | — | US | disclosed |
| US-7741319-B2 | 11-hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2010-06-22 | — | — | US | disclosed |
| US-20100113425-A1 | PYRROLOBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2010-05-06 | — | — | US | disclosed |
| EP-1879901-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2009-12-23 | — | — | EP | disclosed |
| US-7612062-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-20080167293-A1 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2008-07-10 | — | — | US | disclosed |
| US-20070173497-A1 | 11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2007-07-26 | — | — | US | disclosed |
| US-7067511-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2006-06-27 | — | — | US | disclosed |
| US-7049311-B1 | Pyrrolbenzodiazepines | SPIROGEN LIMITED (GB) | 2006-05-23 | — | — | US | disclosed |
| EP-1109812-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2005-05-04 | — | — | EP | disclosed |
| EP-1413582-A1 | Dimeric pyrrolobenzodiazepines | Spirogen Limited (GB) | 2004-04-28 | — | — | EP | disclosed |
| US-20030120069-A1 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2003-06-26 | — | — | US | disclosed |
| EP-1193270-B1 | Pyrrolobenzodiazepines | SPIROGEN LTD (GB) | 2003-05-14 | — | — | EP | disclosed |
| EP-1193270-A2 | Pyrrolobenzodiazepines | Spirogen Limited (GB) | 2002-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113425-A1 | PYRROLOBENZODIAZEPINES | CNR1, MC3R, NPSR1 | HTR2C 201/4885PDK1 3993/4885PDK2 4117/4885 |
| US-20080167293-A1 | Pyrrolobenzodiazepines | CNR1, HRH3, NPSR1 | HTR2C 176/4885PDK1 3936/4885PDK2 3968/4885 |
| US-20070173497-A1 | 11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines | H1-10, DRD1, SBDS | HTR2C 122/4885PDK1 573/4885PDK2 1401/4885 |
| US-20030120069-A1 | Pyrrolobenzodiazepines | CNR1, CBX2, CNR2 | HTR2C 336/4885PDK1 4078/4885PDK2 4104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.