Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 13/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703238 | 1.00 | ABCB1 (0.60) | ABCB1HTR1ADRD2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8703399 | 0.99 | ABCB1 (0.59) | ABCB1HTR1ADRD2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8703779 | 0.99 | ABCB1 (0.59) | ABCB1HTR1ADRD2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8703392 | 0.99 | ABCB1 (0.59) | ABCB1HTR1ADRD2CHRNB4CHRNA3 | |
| SCHEMBL21095169 | 0.86 | ABCB1 (0.59) | ABCB1HTR1ADRD2 | |
| SCHEMBL21095600 | 0.86 | ABCB1 (0.59) | ABCB1HTR1ADRD2 | |
| SCHEMBL21095171 | 0.86 | ABCB1 (0.59) | ABCB1HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8702021 | 0.85 | TP53 (0.57) | ABCB1HTR1ADRD2 | |
| SCHEMBL27341184 | 0.85 | CHRNB4 (0.60) | HTR1ADRD2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8707931 | 0.84 | CHRNB4 (0.59) | HTR1ADRD2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844000-A1 | Use of alpha, omega-diarylalkane derivatives in the treatment and prevention of psychosis | SANKYO COMPANY LIMITED (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5556864-A | TREATMENT OF CIRCULATORY DISEASES AND PSYCHOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0600717-A1 | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis | SANKYO COMPANY LIMITED (JP) | 1994-06-08 | — | — | EP | disclosed |