Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CCKBR | P32239 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SLC15A2 | Q16348 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078000 | 0.89 | MAPT (0.51) | CYP3A4USP2CHRM1PTGS1KMT2A | |
| SCHEMBL11078002 | 0.89 | MAPT (0.51) | CYP3A4USP2CHRM1PTGS1KMT2A | |
| Piperacillin SCHEMBL8704619 | 0.89 | CYP3A4 (0.72) | CYP3A4USP2CHRM1PTGS1KMT2A | |
| Piperacillin SCHEMBL5694576 | 0.84 | MEN1 (0.71) | CYP3A4PTGS1KMT2AMEN1CCKBR | |
| Piperacillin SCHEMBL27678278 | 0.82 | MEN1 (0.73) | PTGS1KMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL24437361 | 0.80 | MEN1 (0.77) | PTGS1KMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL3233001 | 0.80 | MEN1 (0.77) | PTGS1KMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL14506140 | 0.80 | MEN1 (0.77) | PTGS1KMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL4486297 | 0.80 | MEN1 (0.77) | PTGS1KMT2AMEN1CCKBRKDM4E | |
| Piperacillin SCHEMBL11908507 | 0.80 | MEN1 (0.77) | PTGS1KMT2AMEN1CCKBRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | disclosed |