Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacinamide SCHEMBL3980415 | 0.79 | SIRT2 (0.85) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL29440775 | 0.79 | SIRT2 (0.85) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL3690310 | 0.79 | SIRT2 (0.85) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL28378151 | 0.77 | SIRT2 (0.81) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL7753606 | 0.77 | F7 (0.96) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL28589383 | 0.75 | SIRT2 (0.85) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL460466 | 0.75 | F7 (1.00) | SIRT2SIRT1SIRT3F7F3 | |
| Niacinamide SCHEMBL19978192 | 0.75 | — | — | |
| Niacinamide SCHEMBL29624874 | 0.75 | — | — | |
| Niacinamide SCHEMBL2926 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998004127-A2 | TRANSPLANT SOLUTIONS CONTAINING PYRUVATE AND METHODS FOR TRANSPLANTATION | STANKO RONALD T (US) | 1998-02-05 | — | — | WO | disclosed |