Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.76 |
| ▸ | RAB9A | P51151 | 7/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | FLT3 | P36888 | 2/20 | 0.69 |
| ▸ | STK17B | O94768 | 1/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848148 | 1.00 | NPC1 (0.76) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL3263663 | 0.86 | NPC1 (1.00) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL19380254 | 0.85 | NPC1 (0.78) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL8707964 | 0.85 | PIM1 (0.68) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL11843224 | 0.85 | NPC1 (0.78) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL14124819 | 0.85 | NPC1 (0.84) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL8761650 | 0.84 | NPC1 (1.00) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL2507064 | 0.84 | NPC1 (0.76) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL11109735 | 0.84 | NPC1 (0.81) | NPC1RAB9AMAPK1TSHRKMT2A | |
| SCHEMBL29847278 | 0.84 | NPC1 (1.00) | NPC1RAB9AMAPK1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733912-A | NERVOUS SYSTEM DISORDERS IN NERVE CELLS | ABBOTT LABORATORIES (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0778274-A1 | Amidinohydrazones of ketones derived from benzo(b)furan, process for their preparation and medicaments containing these compounds | Helopharm G. Petrik GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |