Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.57 |
| ▸ | RXRA | P19793 | 11/20 | 0.57 |
| ▸ | RARG | P13631 | 11/20 | 0.57 |
| ▸ | RARA | P10276 | 9/20 | 0.57 |
| ▸ | RXRB | P28702 | 7/20 | 0.57 |
| ▸ | RXRG | P48443 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586132 | 0.85 | RXRA (0.47) | RARBRXRARARGRARARXRB | |
| SCHEMBL8332031 | 0.84 | RXRA (0.59) | RARBRXRARARGRARARXRB | |
| SCHEMBL8582315 | 0.84 | RXRA (0.51) | RARBRXRARARGRARARXRB | |
| SCHEMBL8704772 | 0.83 | RXRA (0.54) | RARBRXRARARGRARARXRB | |
| SCHEMBL8610556 | 0.83 | RXRA (0.56) | RARBRXRARARGRARARXRB | |
| SCHEMBL8331493 | 0.81 | RXRA (0.58) | RARBRXRARARGRARARXRB | |
| SCHEMBL8695594 | 0.81 | RXRA (0.58) | RARBRXRARARGRARARXRB | |
| SCHEMBL8333903 | 0.80 | RXRA (0.59) | RARBRXRARARGRARARXRB | |
| SCHEMBL8332132 | 0.79 | RXRA (0.60) | RARBRXRARARGRARARXRB | |
| SCHEMBL2194599 | 0.78 | RARB (0.82) | RARBRXRARARGRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837725-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1998-11-17 | — | — | US | disclosed |