Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708594 | 1.00 | KLK5 (0.52) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8708735 | 0.91 | KLK5 (0.51) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8708738 | 0.91 | KLK5 (0.51) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8713521 | 0.86 | TRPM8 (0.52) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8713524 | 0.86 | TRPM8 (0.52) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4381363 | 0.85 | UGT1A1 (0.54) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8708966 | 0.83 | KLK5 (0.43) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8708969 | 0.83 | KLK5 (0.43) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6443527 | 0.82 | PSEN1 (0.57) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6443524 | 0.82 | PSEN1 (0.57) | KLK5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |