Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15922148 | 0.83 | CYP1A2 (0.47) | MAPTALDH1A1SMN1; SMN2TP53KMT2A | |
| SCHEMBL4262497 | 0.83 | ALDH1A1 (0.42) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL27511679 | 0.81 | MAPT (0.39) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL4255534 | 0.81 | TTR (0.41) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL15335397 | 0.79 | PTPN1 (0.31) | MAPTALDH1A1TDP1KDM4E | |
| SCHEMBL30983713 | 0.79 | KDM4E (0.53) | KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL29210582 | 0.79 | KDM4E (0.53) | KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL15386720 | 0.78 | MAPT (0.37) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL12772142 | 0.78 | MAPT (0.46) | MAPTALDH1A1TDP1KDM4EL3MBTL1 | |
| SCHEMBL2370519 | 0.77 | MAPK1 (0.54) | MAPTALDH1A1TDP1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |