Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198988 | 0.87 | MAPK1 (0.54) | MAPK1SMN1; SMN2L3MBTL1OPRL1HTR1A | |
| SCHEMBL9832235 | 0.86 | MAPK1 (0.53) | MAPK1SMN1; SMN2L3MBTL1OPRL1HTR1A | |
| SCHEMBL32668926 | 0.86 | MAPK1 (0.53) | MAPK1SMN1; SMN2L3MBTL1DRD2HRH1 | |
| SCHEMBL4457894 | 0.86 | MAPK1 (0.53) | MAPK1SMN1; SMN2L3MBTL1DRD2HRH1 | |
| SCHEMBL9592908 | 0.84 | SMN1; SMN2 (0.51) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM1 | |
| SCHEMBL9590406 | 0.83 | MAPK1 (0.50) | MAPK1SMN1; SMN2L3MBTL1DRD2KDM1A | |
| SCHEMBL9591624 | 0.82 | SMN1; SMN2 (0.49) | MAPK1SMN1; SMN2L3MBTL1OPRL1MEN1 | |
| SCHEMBL13921299 | 0.76 | MAPK1 (0.82) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM1 | |
| SCHEMBL10409949 | 0.75 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM1 | |
| SCHEMBL11521605 | 0.75 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998057964-A1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |