Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198988 | 0.92 | MAPK1 (0.54) | MAPK1SMN1; SMN2L3MBTL1PTAFRHTR1F | |
| SCHEMBL32668926 | 0.87 | MAPK1 (0.53) | MAPK1SMN1; SMN2L3MBTL1FNTAFNTB | |
| SCHEMBL4457894 | 0.87 | MAPK1 (0.53) | MAPK1SMN1; SMN2L3MBTL1FNTAFNTB | |
| SCHEMBL8709456 | 0.86 | MAPK1 (0.72) | MAPK1SMN1; SMN2L3MBTL1OPRL1KCNH2 | |
| SCHEMBL9592908 | 0.85 | SMN1; SMN2 (0.51) | MAPK1SMN1; SMN2L3MBTL1OPRL1KCNH2 | |
| SCHEMBL9590406 | 0.84 | MAPK1 (0.50) | MAPK1SMN1; SMN2L3MBTL1CYP11B1DRD2 | |
| SCHEMBL9591624 | 0.83 | SMN1; SMN2 (0.49) | MAPK1SMN1; SMN2L3MBTL1OPRL1FNTA | |
| SCHEMBL10409949 | 0.77 | MAPK1 (0.79) | MAPK1SMN1; SMN2L3MBTL1HTR1FKMT2A | |
| SCHEMBL7136245 | 0.75 | SMN1; SMN2 (0.43) | MAPK1SMN1; SMN2L3MBTL1SRD5A1HTR1F | |
| SCHEMBL6970399 | 0.74 | MAPK1 (0.59) | MAPK1SMN1; SMN2L3MBTL1SRD5A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208855-B1 | PROCESS FOR PREPARING PIPERIDYLIDENE DIHYDRODIBENZO(A,D)CYCLOHEPTENES AND AZA DERIVATIVES THEREOF, COMPOUNDS OBTAINED BY SUCH PROCESS AND THE USE OF SUCH COMPOUNDS FOR PREPARING USEFUL PHARMACEUTICAL COMPOSITIONS | SCHERING CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4659716-A | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines | SCHERING CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0208855-A1 | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions | SCHERING CORPORATION (US) | 1987-01-21 | — | — | EP | disclosed |