Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8705058 | 0.89 | HMGCR (0.46) | HMGCRCHRM1TBXA2RADRA1AKDM4E | |
| SCHEMBL16333661 | 0.86 | — | — | |
| SCHEMBL11422035 | 0.83 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ALMNA | |
| Hydrochloric Acid SCHEMBL27768791 | 0.82 | HMGCR (0.39) | HMGCRCHRM1TBXA2RADRA1AKDM4E | |
| SCHEMBL95244 | 0.81 | — | — | |
| SCHEMBL156638 | 0.81 | — | — | |
| SCHEMBL13895253 | 0.80 | GAA (0.43) | HMGCRCHRM1TBXA2RADRA1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11595783 | 0.79 | — | — | |
| SCHEMBL28122018 | 0.79 | — | — | |
| SCHEMBL16280996 | 0.78 | KDM4E (0.42) | HMGCRCHRM1TBXA2RADRA1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001450-A2 | 3-Hydroxy-3-methylglutaric acid monoamide, derivatives thereof, intermediates, methods of preparation and compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-18 | — | — | EP | claimed |
| US-5849709-A | Saccharopeptides and derivatives thereof | GLYCOMED INCORPORATED (US) | 1998-12-15 | — | — | US | disclosed |
| US-4208204-A | 3-Hydroxy-3-methylglutaric acid monoamide and derivatives thereof | CALBIOCHEM-BEHRING CORP. (US) | 1980-06-17 | — | — | US | disclosed |
| US-4208204-A | 3-Hydroxy-3-methylglutaric acid monoamide and derivatives thereof | CALBIOCHEM-BEHRING CORP. (US) | 1980-06-17 | — | — | US | disclosed |
| EP-0001450-A3 | 3-HYDROXY-3-METHYLGLUTARIC ACID MONOAMIDE, DERIVATIVES THEREOF, INTERMEDIATES, METHODS OF PREPARATION AND COMPOSITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-27 | — | — | EP | disclosed |
| EP-0001450-A2 | 3-Hydroxy-3-methylglutaric acid monoamide, derivatives thereof, intermediates, methods of preparation and compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-18 | — | — | EP | disclosed |
| EP-0001450-A2 | 3-Hydroxy-3-methylglutaric acid monoamide, derivatives thereof, intermediates, methods of preparation and compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-18 | — | — | EP | disclosed |