Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.62 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.58 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27696314 | 0.90 | GPBAR1 (0.64) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL9498149 | 0.89 | ALOX5 (0.69) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL8648447 | 0.87 | GPBAR1 (0.60) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL8712488 | 0.86 | GPBAR1 (0.59) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL8709589 | 0.84 | CYSLTR1 (0.63) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL8651391 | 0.83 | GPBAR1 (0.65) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL10410427 | 0.82 | GPBAR1 (0.64) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL8647826 | 0.82 | GPBAR1 (0.52) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL8715482 | 0.81 | CYSLTR2 (0.60) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 | |
| SCHEMBL7603712 | 0.81 | GPBAR1 (0.70) | GPBAR1CYSLTR1CYSLTR2ALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998014429-A1 | HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1998-04-09 | — | — | WO | disclosed |