⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215990 | 0.88 | APAF1 (0.32) | — | |
| SCHEMBL19004321 | 0.69 | — | — | |
| SCHEMBL27952709 | 0.60 | — | — | |
| SCHEMBL10515564 | 0.60 | MAPT (0.31) | — | |
| SCHEMBL1978035 | 0.59 | — | — | |
| SCHEMBL11228217 | 0.58 | — | — | |
| Hydrochloric Acid SCHEMBL3904361 | 0.58 | — | — | |
| SCHEMBL8576907 | 0.58 | — | — | |
| SCHEMBL28158852 | 0.57 | — | — | |
| SCHEMBL15063081 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208912-A1 | MTA-Cooperative PRMT5 Inhibitors | MIRATI THERAPEUTICS INC (US) | 2024-06-27 | — | — | US | claimed |
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | claimed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | claimed |
| EP-2922543-B1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-05-24 | — | — | EP | claimed |
| US-9273033-B2 | Substituted pyridone derivatives as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-03-01 | — | — | US | claimed |
| US-20150291561-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-15 | — | — | US | claimed |
| EP-2922543-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-09-30 | — | — | EP | claimed |
| WO-2014081617-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-30 | — | — | WO | claimed |
| JP-10045762-A | — | — | None | — | — | JP | disclosed |
| WO-2025217007-A1 | COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER | Mirati Therapeutics, Inc. (US) | 2025-10-16 | — | — | WO | disclosed |
| WO-2025217008-A1 | COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER | Mirati Therapeutics, Inc. (US) | 2025-10-16 | — | — | WO | disclosed |
| WO-2025217015-A1 | COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER | Mirati Therapeutics, Inc. (US) | 2025-10-16 | — | — | WO | disclosed |
| US-20250312351-A1 | COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER | Mirati Therapeutics, Inc. (US) | 2025-10-09 | — | — | US | disclosed |
| US-20250312344-A1 | COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER | Mirati Therapeutics, Inc. (US) | 2025-10-09 | — | — | US | disclosed |
| EP-2922543-B1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2017-05-24 | — | — | EP | disclosed |
| US-9273033-B2 | Substituted pyridone derivatives as PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20150291561-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2922543-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014081617-A1 | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-30 | — | — | WO | disclosed |
| JP-H1045762-A | PRODUCTION OF OXOTETRAHYDROINDOLIZINE DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1998-02-17 | — | — | JP | disclosed |