Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708250 | 0.84 | GAA (0.64) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL571262 | 0.84 | GAA (0.68) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL20630832 | 0.82 | GAA (0.66) | GAAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8802445 | 0.81 | GAA (0.54) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL8810376 | 0.80 | GAA (0.51) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL8811329 | 0.80 | GAA (0.46) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL8711075 | 0.79 | GAA (0.57) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL9573808 | 0.78 | GAA (0.44) | GAAALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL8706384 | 0.76 | ALDH1A1 (0.52) | GAAALDH1A1HPGDGLAMAPT | |
| SCHEMBL8811388 | 0.76 | GAA (0.44) | GAAALDH1A1HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717112-A | Benzofuranone and benzodifuranone compounds | ZENECA LIMITED (GB) | 1998-02-10 | — | — | US | disclosed |
| EP-0669922-B1 | BENZOFURANONES, BENZODIFURANTRIONES AND PROCESSES FOR THE PREPARATION OF BENZODIFURANDIONES | BASF AG (DE) | 1997-08-20 | — | — | EP | disclosed |
| US-5625080-A | Benzodifurantrione compounds and process | ZENECA LIMITED (GB) | 1997-04-29 | — | — | US | disclosed |
| EP-0669922-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES. | ZENECA LTD (GB) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994012501-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES | ZENECA LIMITED (GB) | 1994-06-09 | — | — | WO | disclosed |
| US-4916240-A | Hetero-polycyclic aromatic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-04-10 | — | — | US | disclosed |
| EP-0294029-A2 | Hetero-polycyclic aromatic compounds | ZENECA LIMITED (GB) | 1988-12-07 | — | — | EP | disclosed |