SCHEMBL8711474

SCHEMBL8711474

O=C(OCc1ccccc1)N1CCC2(CC1)CN(C(=O)N1CCCC1)c1ccccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
P2RY1 P47900 1/20 0.51
XIAP P98170 1/20 0.49
BIRC2 Q13490 1/20 0.49
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
NOTUM Q6P988 2/20 0.44
TACR1 P25103 2/20 0.44
NPC1L1 Q9UHC9 1/20 0.44
CYP2C19 P33261 1/20 0.44
KDM1A O60341 2/20 0.43
ENPP2 Q13822 1/20 0.43
ATXN2 Q99700 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14530335 0.86 HDAC1 (0.59) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL26969728 0.86 HDAC1 (0.61) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL14530334 0.86 HDAC1 (0.61) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL6395630 0.84 HDAC1 (0.57) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL26969693 0.83 HDAC1 (0.56) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL2800892 0.83 HDAC1 (0.56) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL14529872 0.83 HDAC1 (0.56) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL1195680 0.83 HDAC1 (0.63) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL1195682 0.83 HDAC1 (0.63) HDAC1HDAC8HDAC6P2RY1XIAP
SCHEMBL21989213 0.83 HDAC1 (0.55) HDAC1HDAC8HDAC6P2RY1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998018762-A1 NEW DERIVATIVES OF DIVERSELY SUBSTITUTED CYCLICAL AMIDE SELECTIVE ANTAGONISTS OF THE HUMAN RECEPTOR NK3, PROCESS FOR OBTAINING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANOFI (FR) 1998-05-07 WO disclosed