Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14530335 | 0.84 | HDAC1 (0.59) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL26969728 | 0.84 | HDAC1 (0.61) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL14530334 | 0.84 | HDAC1 (0.61) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL8711474 | 0.83 | HDAC1 (0.58) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL6395630 | 0.82 | HDAC1 (0.57) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL30733410 | 0.82 | HDAC1 (0.58) | HDAC1HDAC6HDAC8P2RY1MEN1 | |
| SCHEMBL2800892 | 0.82 | HDAC1 (0.56) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL14529872 | 0.82 | HDAC1 (0.56) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL1195682 | 0.82 | HDAC1 (0.63) | HDAC1HDAC6HDAC8P2RY1XIAP | |
| SCHEMBL1195680 | 0.82 | HDAC1 (0.63) | HDAC1HDAC6HDAC8P2RY1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | HDAC1 2067/4885HDAC6 526/4885HDAC8 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.