Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716281 | 0.76 | HRH4 (0.49) | HRH3CHRNA7HRH4MTNR1AMTNR1B | |
| SCHEMBL8332622 | 0.71 | HRH3 (0.65) | HRH3CHRNA7HRH4MTNR1AMTNR1B | |
| SCHEMBL3990045 | 0.70 | HRH3 (0.63) | HRH3CHRNA7HRH4LOXL2DRD2 | |
| SCHEMBL5442333 | 0.70 | HRH4 (0.70) | HRH3CHRNA7HRH4LOXL2DRD2 | |
| SCHEMBL29744181 | 0.70 | HRH4 (0.70) | HRH3CHRNA7HRH4LOXL2DRD2 | |
| SCHEMBL8714113 | 0.70 | HRH4 (0.60) | HRH3HRH4KDR | |
| SCHEMBL3448677 | 0.69 | HRH3 (0.45) | HRH3CHRNA7HRH4MTNR1AMTNR1B | |
| SCHEMBL7169246 | 0.68 | LOXL2 (0.69) | HRH3CHRNA7HRH4MTNR1AMTNR1B | |
| SCHEMBL31059889 | 0.68 | LOXL2 (0.69) | HRH3CHRNA7HRH4MTNR1AMTNR1B | |
| SCHEMBL1160528 | 0.68 | LOXL2 (0.55) | HRH3CHRNA7HRH4MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822939-A1 | CYCLIC PENTAPEPTIDE LH-RH RECEPTOR ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996034012-A1 | CYCLIC PENTAPEPTIDE LH-RH RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |