SCHEMBL8713002

SCHEMBL8713002

COc1ccc(N2Cc3cnccc3C2=O)cc1OC1CCc2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 9/20 0.45
NOX1 Q9Y5S8 2/20 0.44
NPC1 O15118 1/20 0.41
PKM P14618 1/20 0.41
RAB9A P51151 1/20 0.41
CYP11B2 P19099 1/20 0.41
CMA1 P23946 1/20 0.40
MCHR1 Q99705 2/20 0.39
HTR2A P28223 4/20 0.39
HTR2B P41595 4/20 0.39
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38
PDE4D Q08499 1/20 0.38
PIK3CG P48736 1/20 0.37
UGCG Q16739 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8713359 0.99 HTR2C (0.44) HTR2CNOX1NPC1PKMRAB9A
SCHEMBL8707686 0.83 NPC1 (0.46) HTR2CNOX1NPC1PKMRAB9A
SCHEMBL8713427 0.83 HTR2C (0.42) HTR2CNOX1CMA1MCHR1HTR2A
SCHEMBL8708977 0.83 HTR2C (0.49) HTR2CNPC1PKMRAB9ACYP11B2
SCHEMBL8707098 0.82 NOX1 (0.41) NOX1CMA1MCHR1PDE4APDE4B
SCHEMBL7698109 0.81 PDE4D (0.46) HTR2CPDE4APDE4BPDE4CPDE4D
SCHEMBL8713389 0.81 HTR2C (0.47) HTR2CPDE4APDE4BPDE4CPDE4D
SCHEMBL8708949 0.80 HTR2C (0.46) HTR2CNOX1NPC1PKMRAB9A
SCHEMBL8711349 0.80 HTR2C (0.46) HTR2CNPC1PKMRAB9ACMA1
Hydrochloric Acid SCHEMBL8710356 0.80 HTR2C (0.46) HTR2CPDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998042666-A1 NOVEL 3,4-DIALKOXYPHENYL DERIVATIVES AND THE USE THEREOF DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 1998-10-01 WO disclosed