Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclosporine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA known ✓ | P62937 | 5/20 | 0.94 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.94 |
| ▸ | PPP3CA | Q08209 | 3/20 | 0.94 |
| ▸ | FKBP1B | P68106 | 2/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 1/20 | 0.94 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
| ▸ | USP2 | O75604 | 1/20 | 0.94 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.94 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | POLB | P06746 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | RARB | P10826 | 1/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.94 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.94 |
| ▸ | TACR2 | P21452 | 1/20 | 0.94 |
| ▸ | PPIB | P23284 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclosporine SCHEMBL8713001 | 1.00 | ABCB1 (0.94) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL2973381 | 0.97 | ABCB1 (0.95) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL2973383 | 0.97 | ABCB1 (0.95) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24224445 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239446 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239036 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192319 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL25083206 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192320 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL22123717 | 0.97 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750413-A | FLUORESCENT MARKERS FOR CYCLOSPORINS | ABBOTT LABORATORIES | 1998-05-12 | — | — | US | disclosed |
| US-5489668-A | DERIVATIVES LABELED WITH DETECTABLE FLUORESCEIN MOIETY FOR USE AS TRACERS | ABBOTT LABORATORIES (US) | 1996-02-06 | — | — | US | disclosed |
| EP-0473961-B1 | Immunoassay reagents and method for determining cyclosporine | ABBOTT LAB (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0471295-B1 | Protein precipitation reagent | ABBOTT LAB (US) | 1995-11-08 | — | — | EP | disclosed |
| US-5135875-A | PROTEIN PRECIPITATION REAGENT | ABBOTT LABORATORIES (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0473961-A2 | Immunoassay reagents and method for determining cyclosporine | ABBOTT LABORATORIES (US) | 1992-03-11 | — | — | EP | disclosed |
| EP-0471295-A1 | Protein precipitation reagent | ABBOTT LABORATORIES (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0471293-A2 | Solubilization reagent for biological test samples | ABBOTT LABORATORIES (US) | 1992-02-19 | — | — | EP | disclosed |