Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclosporine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA known ✓ | P62937 | 5/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 13/20 | 1.00 |
| ▸ | PPP3CA | Q08209 | 3/20 | 1.00 |
| ▸ | FKBP1B | P68106 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 1/20 | 1.00 |
| ▸ | TACR2 | P21452 | 1/20 | 1.00 |
| ▸ | PPIB | P23284 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclosporine SCHEMBL21170318 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| SCHEMBL23382247 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239446 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24224445 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL25083206 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239035 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192320 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| SCHEMBL23110210 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239036 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192319 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104958754-A | Cyclosporine cream for treating lupus erythematosus or psoriasis, method for manufacturing cyclosporine cream and application thereof | JIUHUI PHARMACEUTICAL CO LTD | 2015-10-07 | — | — | CN | claimed |
| US-12458704-B2 | Multimeric elastin-like polypeptides | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2025-11-04 | — | — | US | disclosed |
| US-12070442-B2 | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease | SURFACE OPHTHALMICS, INC. (US) | 2024-08-27 | — | — | US | disclosed |
| US-20230277557-A1 | PHARMACEUTICAL KITS AND THEIR USE FOR TREATING DRY EYE DISEASE | SURFACE OPHTHALMICS INC (US) | 2023-09-07 | — | — | US | disclosed |
| US-20230181752-A1 | MULTIMERIC ELASTIN-LIKE POLYPEPTIDES | UNIVERSITY OF SOUTHERN CALIFORNIA | 2023-06-15 | — | — | US | disclosed |
| EP-3899048-A1 | PYRROLOBENZODIAZEPINE RESISTANCE | ADC Therapeutics SA (CH) | 2021-10-27 | — | — | EP | disclosed |
| CN-108697644-B | Method for producing particles | 株式会社理光 | 2021-10-22 | — | — | CN | disclosed |
| CN-108675935-B | Preparation method of 1, 1-diaryl alkane compound | 南昌航空大学 | 2020-08-28 | — | — | CN | disclosed |
| WO-2020127573-A1 | PYRROLOBENZODIAZEPINE RESISTANCE | ADC THERAPEUTICS SA (CH) | 2020-06-25 | — | — | WO | disclosed |
| CN-104958754-B | A kind of cyclosporin emulsifiable paste and its preparation method and application for treating lupus erythematosus or psoriasis | 惠州市九惠制药股份有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-104958754-A | Cyclosporine cream for treating lupus erythematosus or psoriasis, method for manufacturing cyclosporine cream and application thereof | JIUHUI PHARMACEUTICAL CO LTD | 2015-10-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12458704-B2 | Multimeric elastin-like polypeptides | MICA, SERPINA2, DNASE1L3 | PPIA 443/4885ABCB1 281/4885PPP3CA 333/4885 |
| US-12070442-B2 | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease | EYA3, HSD3B1, HMGCR | PPIA 940/4885ABCB1 1144/4885PPP3CA 12/4885 |
| US-20230181752-A1 | MULTIMERIC ELASTIN-LIKE POLYPEPTIDES | MICA, SERPINA2, DNASE1L3 | PPIA 443/4885ABCB1 281/4885PPP3CA 333/4885 |
| US-20230277557-A1 | PHARMACEUTICAL KITS AND THEIR USE FOR TREATING DRY EYE DISEASE | TSLP, SERPINA6, IL5 | PPIA 2130/4885ABCB1 1265/4885PPP3CA 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.