Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714142 | 0.82 | HSD11B1 (0.46) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8712047 | 0.79 | HSD11B1 (0.48) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8711712 | 0.78 | HSD11B1 (0.46) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8712265 | 0.78 | HSD11B1 (0.45) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8714834 | 0.77 | HSD11B1 (0.46) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8715332 | 0.74 | HSD11B1 (0.55) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8711959 | 0.74 | RXFP1 (0.42) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL8714197 | 0.73 | HSD11B1 (0.43) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL9229216 | 0.73 | HSD11B1 (0.49) | HSD11B1KMT2ALMNACYP2D6CYP2C19 | |
| SCHEMBL9231944 | 0.72 | CYP2D6 (0.54) | HSD11B1KMT2ALMNACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |