SCHEMBL8713407

SCHEMBL8713407

C[C@@H]1C[C@@H](n2c(=O)oc3ccccc32)CCN1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 3/20 0.47
TNKS O95271 3/20 0.46
CHRM4 P08173 1/20 0.44
CHRM5 P08912 1/20 0.44
CHRM1 P11229 1/20 0.44
MAPK1 P28482 2/20 0.42
USP2 O75604 1/20 0.42
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
ADRA1D P25100 4/20 0.40
ADRA1A P35348 4/20 0.40
ADRA1B P35368 4/20 0.40
HTR2A P28223 1/20 0.40
HTR7 P34969 1/20 0.40
PLD1 Q13393 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
POLB P06746 1/20 0.39
PARP1 P09874 2/20 0.38
PARP2 Q9UGN5 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL830500 0.81 TNKS (0.51) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL16997531 0.79 TNKS (0.57) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL22605448 0.74 ADRA1D (0.57) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL16883711 0.74 CHRM1 (0.53) CHRM4CHRM1PLD1
SCHEMBL15599596 0.73 TNKS (0.54) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL15599591 0.73 TNKS (0.54) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL16989701 0.73 TNKS (0.54) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL16456354 0.72 TNKS (0.54) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL16455967 0.72 TNKS (0.54) HSD11B1TNKSCHRM4CHRM5CHRM1
SCHEMBL20845723 0.71 HTR2A (0.46) HSD11B1TNKSCHRM4CHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812196-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1998-05-20 EP disclosed
EP-0812196-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1997-12-17 EP disclosed
WO-1996025934-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-08-29 WO disclosed