Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27499001 | 0.87 | CYP19A1 (0.47) | HRH3CYP19A1 | |
| Hydrochloric Acid SCHEMBL27498708 | 0.85 | CYP19A1 (0.46) | HRH3CYP19A1 | |
| SCHEMBL8784962 | 0.80 | CYP19A1 (0.57) | NPC1RAB9ASIGMAR1CYP19A1HTR1A | |
| SCHEMBL6761768 | 0.75 | CYP19A1 (0.61) | HRH3NPC1MAPTRAB9ASLC6A3 | |
| SCHEMBL10247481 | 0.75 | HMOX1 (0.57) | — | |
| Hydrochloric Acid SCHEMBL410087 | 0.74 | HMOX1 (0.56) | — | |
| SCHEMBL2158738 | 0.73 | TSHR (0.47) | NPC1RAB9ACYP19A1 | |
| SCHEMBL10288500 | 0.72 | CYP19A1 (0.47) | HRH3RAB9AMGLLCYP19A1 | |
| SCHEMBL27519760 | 0.72 | CYP19A1 (0.56) | HRH3RAB9AMGLLCYP19A1HTR1A | |
| SCHEMBL1776600 | 0.71 | HMOX1 (0.41) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |