Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871565 | 0.85 | MCHR1 (0.48) | MCHR1RET | |
| SCHEMBL871431 | 0.85 | MCHR1 (0.44) | MCHR1 | |
| SCHEMBL871432 | 0.84 | DRD2 (0.42) | DRD4MCHR1DRD2SUV39H2 | |
| SCHEMBL870156 | 0.84 | MCHR1 (0.53) | MCHR1 | |
| SCHEMBL10025923 | 0.83 | MCHR1 (0.51) | MCHR1 | |
| SCHEMBL870726 | 0.82 | MCHR1 (0.56) | MCHR1 | |
| SCHEMBL1779926 | 0.80 | MCHR1 (0.48) | MCHR1 | |
| SCHEMBL1779922 | 0.79 | MCHR1 (0.49) | MCHR1 | |
| SCHEMBL876575 | 0.79 | MCHR1 (0.53) | MCHR1 | |
| SCHEMBL870132 | 0.79 | MCHR1 (0.55) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077794-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXSMITHKLINE LLC (US) | 2012-03-29 | — | — | US | disclosed |
| WO-2010141538-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077794-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | MCHR1, MCHR2, MC1R | DRD4 543/4885MCHR1 1/4885RET 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.