Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715154 | 1.00 | ALDH1A1 (0.63) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8714793 | 0.90 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8714791 | 0.90 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8713370 | 0.89 | MAPT (0.66) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8713366 | 0.89 | MAPT (0.66) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8717977 | 0.87 | MAPT (0.64) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8717976 | 0.87 | MAPT (0.64) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8717517 | 0.85 | MAPT (0.61) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8717514 | 0.85 | MAPT (0.61) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL8714219 | 0.84 | MAPT (0.60) | ALDH1A1MAPTLMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | claimed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | claimed |
| EP-0843660-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-05-27 | — | — | EP | disclosed |
| US-5696148-A | POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE | NOVO NORDISK A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997005109-A1 | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-02-13 | — | — | WO | disclosed |