Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.32 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.32 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712087 | 1.00 | KDM4C (0.32) | KDM4CCYSLTR2CYSLTR1TMPRSS4EGLN1 | |
| SCHEMBL8709839 | 0.91 | GRM4 (0.34) | KDM4CCYSLTR2CYSLTR1TMPRSS4EGLN1 | |
| SCHEMBL8709842 | 0.91 | GRM4 (0.34) | KDM4CCYSLTR2CYSLTR1TMPRSS4EGLN1 | |
| SCHEMBL8715533 | 0.89 | MAPT (0.37) | PKMKMT2A | |
| SCHEMBL8715532 | 0.89 | MAPT (0.37) | PKMKMT2A | |
| SCHEMBL8710693 | 0.88 | MEN1 (0.35) | KMT2A | |
| SCHEMBL8710689 | 0.88 | MEN1 (0.35) | KMT2A | |
| SCHEMBL8713451 | 0.86 | ELANE (0.34) | — | |
| SCHEMBL8713450 | 0.86 | ELANE (0.34) | — | |
| SCHEMBL8709849 | 0.85 | TLR7 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |