Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715178 | 0.87 | HDAC8 (0.53) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715218 | 0.81 | HDAC8 (0.53) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715420 | 0.80 | HDAC8 (0.52) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8305408 | 0.79 | HDAC8 (0.60) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715413 | 0.78 | HDAC8 (0.65) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9414745 | 0.75 | HDAC8 (0.57) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715374 | 0.75 | HDAC8 (0.57) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8308839 | 0.73 | PSEN1 (0.69) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL445137 | 0.68 | HDAC8 (1.00) | HDAC8 | |
| SCHEMBL1754734 | 0.66 | TSHR (0.53) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |