Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414745 | 1.00 | HDAC8 (0.57) | HDAC8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8715413 | 0.81 | HDAC8 (0.65) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8305408 | 0.78 | HDAC8 (0.60) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715178 | 0.77 | HDAC8 (0.53) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715218 | 0.77 | HDAC8 (0.53) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8308839 | 0.76 | PSEN1 (0.69) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715202 | 0.75 | HDAC8 (0.52) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8715420 | 0.75 | HDAC8 (0.52) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11458420 | 0.73 | CYP1B1 (0.55) | MAPTMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL11458421 | 0.73 | CYP1B1 (0.55) | MAPTMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |