Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.65 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.65 |
| ▸ | FLT1 | P17948 | 4/20 | 0.65 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.65 |
| ▸ | RET | P07949 | 7/20 | 0.62 |
| ▸ | KIF5B | P33176 | 6/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459697 | 0.93 | KDR (0.74) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL7452267 | 0.92 | KDR (0.74) | KDREPHA2FLT1EPHB4RET | |
| Hydrochloric Acid SCHEMBL7452936 | 0.91 | KDR (0.73) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL7864670 | 0.83 | KDR (0.80) | KDREPHA2FLT1RETKIF5B | |
| SCHEMBL8307447 | 0.82 | KDR (0.76) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL7454466 | 0.82 | KDR (0.78) | KDREPHA2FLT1EPHB4RET | |
| Hydrochloric Acid SCHEMBL7455631 | 0.81 | KDR (0.77) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL7452916 | 0.81 | KDR (0.69) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL8203666 | 0.80 | KDR (0.74) | KDREPHA2FLT1EPHB4RET | |
| SCHEMBL7446874 | 0.80 | KDR (0.56) | KDREPHA2FLT1EPHB4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873319-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997022596-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |