Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 10/20 | 0.45 |
| ▸ | CNR2 | P34972 | 10/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715395 | 0.92 | KDM1A (0.47) | KDM1ANR1H4CNR1CNR2TAS1R3 | |
| SCHEMBL8410563 | 0.84 | KDM1A (0.48) | KDM1ACNR1CNR2PRSS1PRSS2 | |
| SCHEMBL8407420 | 0.79 | NPC1 (0.53) | PRSS1PRSS2PRSS3ST14DRD2 | |
| SCHEMBL8410171 | 0.76 | CFTR (0.48) | KDM1AL3MBTL1PRSS1PRSS2PRSS3 | |
| SCHEMBL8410733 | 0.74 | POLB (0.55) | NR1H4ALDH1A1POLB | |
| SCHEMBL8407182 | 0.74 | SMYD3 (0.49) | PRSS1PRSS2PRSS3ST14DRD2 | |
| Hydrochloric Acid SCHEMBL8949029 | 0.73 | CNR2 (0.49) | CNR1CNR2RAB9A | |
| Hydrochloric Acid SCHEMBL4733281 | 0.72 | PDE4B (0.50) | KDM1AL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL21482092 | 0.72 | NAAA (0.43) | CNR1CNR2POLBDRD3KCNH2 | |
| SCHEMBL9568223 | 0.72 | ST14 (0.40) | KDM1APRSS1PRSS2PRSS3ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | claimed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |