Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712643 | 0.81 | RET (0.44) | RETHTR2ACHRNA7CHRNB2CHRNA4 | |
| SCHEMBL6965256 | 0.80 | MAPT (0.47) | RETHTR2ACYP2D6 | |
| SCHEMBL19359221 | 0.79 | IDO1 (0.56) | RETHTR2AIDO1 | |
| SCHEMBL30729415 | 0.77 | RET (0.66) | RETHTR2ACYP2D6 | |
| SCHEMBL13447594 | 0.77 | HTR2A (0.47) | RETHTR2ACHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7979437 | 0.76 | HTR2A (0.47) | RETHTR2ACHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7965950 | 0.76 | HTR2A (0.47) | RETHTR2AIDO1 | |
| SCHEMBL7468970 | 0.74 | KCNA3 (0.45) | RETHTR2ACYP2D6 | |
| SCHEMBL9084723 | 0.74 | KDM4E (0.38) | RETHTR2ACHRNA7CHRNB2CHRNA4 | |
| SCHEMBL9084730 | 0.74 | KDM4E (0.38) | RETHTR2ACHRNA7CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820442-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031474-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |