Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302585 | 0.81 | MAPT (0.46) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8302569 | 0.80 | MAPT (0.42) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8714625 | 0.77 | KMT2A (0.43) | MAPTMEN1KMT2ATP53TSHR | |
| SCHEMBL8307491 | 0.77 | GRIA2 (0.45) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8307154 | 0.76 | HDAC8 (0.52) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8302587 | 0.75 | PDE4B (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8300364 | 0.74 | TBXA2R (0.45) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8911880 | 0.73 | PDE3B (0.39) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8302588 | 0.73 | PDE3B (0.44) | MAPTPDE3BPDE3APDE4APDE4B | |
| SCHEMBL8291586 | 0.73 | PDE3B (0.41) | MAPTPDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |