Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308772 | 0.82 | HDAC8 (0.46) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8715566 | 0.75 | MAPT (0.44) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8714625 | 0.72 | KMT2A (0.43) | — | |
| SCHEMBL11318812 | 0.67 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8302610 | 0.63 | LMNA (0.46) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL8306283 | 0.63 | LMNA (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL10596136 | 0.62 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL12699910 | 0.61 | HRH3 (0.56) | HRH3 | |
| SCHEMBL1640654 | 0.61 | PDE3B (0.46) | PDE4BPDE3BPDE3AHRH3 | |
| SCHEMBL8685634 | 0.60 | ALDH1A1 (0.54) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |