Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710175 | 0.89 | KDM4E (0.36) | HTR1ASLC6A2SLC6A4PTGDR2LRRK2 | |
| SCHEMBL8710219 | 0.89 | CYP3A4 (0.44) | PTGDR2LRRK2KDM4EALDH1A1CYP3A4 | |
| SCHEMBL23393405 | 0.70 | ABCB1 (0.56) | SRCTGFBR1PTGDR2ABCB1KDM4E | |
| SCHEMBL30070859 | 0.70 | ABCB1 (0.56) | SRCTGFBR1PTGDR2ABCB1KDM4E | |
| SCHEMBL8709054 | 0.70 | CYP3A4 (0.47) | PTGDR2LRRK2KDM4EALDH1A1CYP3A4 | |
| SCHEMBL21483107 | 0.70 | MAPT (0.50) | SRCTGFBR1PTGDR2ABCB1ALDH1A1 | |
| SCHEMBL30070841 | 0.70 | MAPT (0.50) | SRCTGFBR1PTGDR2ABCB1ALDH1A1 | |
| SCHEMBL21483284 | 0.69 | POLB (0.49) | SRCTGFBR1PTGDR2RAB9AABCB1 | |
| SCHEMBL8709890 | 0.69 | RAB9A (0.37) | RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8710460 | 0.68 | HPGD (0.47) | RAB9AKDM4EALDH1A1CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |