Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | PREP | P48147 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718628 | 1.00 | CA12 (0.35) | CA12CA1CA9PREPKMT2A | |
| SCHEMBL8714967 | 0.86 | HSP90AA1 (0.44) | CA12CA1CA9 | |
| SCHEMBL8714970 | 0.86 | HSP90AA1 (0.44) | CA12CA1CA9 | |
| SCHEMBL8715900 | 0.81 | GSK3B (0.43) | — | |
| SCHEMBL8715903 | 0.81 | GSK3B (0.43) | — | |
| SCHEMBL8715880 | 0.78 | ALDH1A1 (0.36) | KMT2A | |
| SCHEMBL8715879 | 0.78 | ALDH1A1 (0.36) | KMT2A | |
| SCHEMBL7366745 | 0.77 | PREP (0.40) | CA12CA1CA9PREPKMT2A | |
| SCHEMBL7366750 | 0.77 | PREP (0.40) | CA12CA1CA9PREPKMT2A | |
| SCHEMBL8715871 | 0.77 | CACNA1B (0.37) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722448-A4 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693648-A | TREATMENT OF AUTOIMMUNE DISEASES, INFECTIOUS DISEASES, PREVENTING REJECTION OF ORGAN TRANSPLANTS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5565560-A | TREATING AUTOIMMUNE DISEASES, PREVENTING TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0722448-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO. INC. (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5532248-A | O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity | MERCK CO., INC. (US) | 1996-07-02 | — | — | US | disclosed |
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| US-5250678-A | For autoimmune, infectious diseases, organ transplant rejection; skin diseases, antiinflammatory agents | MERCK & CO., INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | disclosed |