Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499695 | 0.90 | PNMT (0.47) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL27762485 | 0.88 | PNMT (0.43) | PNMTNPC1RAB9ASIGMAR1HTR7 | |
| SCHEMBL2177653 | 0.85 | PNMT (0.51) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL499896 | 0.76 | PNMT (0.49) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL23777720 | 0.76 | PNMT (0.46) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL3952483 | 0.76 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL6421463 | 0.76 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL30462691 | 0.75 | PNMT (0.47) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL19418539 | 0.75 | PNMT (0.47) | PNMTNPC1RAB9AHTR7HTR2B | |
| Hexane SCHEMBL8572947 | 0.74 | PNMT (0.47) | PNMTNPC1RAB9ASIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871631-A1 | ANTIPARASITIC MARCFORTINES AND PARAHERQUAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997003988-A1 | ANTIPARASITIC MARCFORTINES AND PARAHERQUAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-06 | — | — | WO | disclosed |