Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721611 | 0.86 | TOP2A (0.49) | TOP2ATOP2BPDGFRA | |
| SCHEMBL8719830 | 0.84 | TOP2A (0.49) | TOP2ATOP2BNQO2PDGFRA | |
| SCHEMBL8719777 | 0.82 | TOP2A (0.52) | TOP2ATOP2B | |
| SCHEMBL10811874 | 0.82 | TOP2A (0.50) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8716881 | 0.80 | TOP2A (0.40) | TOP2A | |
| SCHEMBL10815975 | 0.80 | TOP2A (0.49) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8721606 | 0.80 | TOP2A (0.35) | TOP2ATOP2B | |
| SCHEMBL10811401 | 0.79 | TOP2A (0.50) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL8482943 | 0.78 | TOP2A (0.42) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10816586 | 0.78 | TOP2A (0.47) | TOP2ATOP2BPOLBNPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837861-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997002267-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | UNIVERSITY OF VERMONT (US) | 1997-01-23 | — | — | WO | disclosed |