Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | NQO2 | P16083 | 2/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | NQO1 | P15559 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721611 | 0.93 | TOP2A (0.49) | TOP2ADYRK3RPS6KB1EPHA2FLT4 | |
| SCHEMBL8719777 | 0.90 | TOP2A (0.52) | TOP2ADYRK3RPS6KB1EPHA2FLT4 | |
| SCHEMBL8716808 | 0.84 | TOP2A (0.42) | TOP2ATOP2BNQO2PDGFRA | |
| SCHEMBL8485663 | 0.82 | TOP2A (0.46) | TOP2A | |
| SCHEMBL8721606 | 0.82 | TOP2A (0.35) | TOP2ATOP2B | |
| SCHEMBL8485927 | 0.81 | TOP2A (0.47) | TOP2A | |
| SCHEMBL8716881 | 0.81 | TOP2A (0.40) | TOP2A | |
| SCHEMBL10811401 | 0.79 | TOP2A (0.50) | TOP2AKAT2BDYRK3RPS6KB1EPHA2 | |
| SCHEMBL10809616 | 0.78 | TOP2A (0.61) | TOP2ADYRK3RPS6KB1EPHA2FLT4 | |
| SCHEMBL10807061 | 0.77 | TOP2A (0.66) | TOP2ATOP2BNQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837861-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1997002267-A1 | NEW PYRIDO-THIOPYRANOINDAZOLES WITH ANTITUMOR ACTIVITY | UNIVERSITY OF VERMONT (US) | 1997-01-23 | — | — | WO | disclosed |