SCHEMBL8716964

SCHEMBL8716964

CCOC(=O)CN(C(=O)[C@H](CC(=O)O)NC(=O)OC(C)(C)C)C(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.41
CTSK P43235 6/20 0.40
CTSS P25774 4/20 0.40
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
CYP2D6 P10635 1/20 0.36
CTSL P07711 1/20 0.36
CTSB P07858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331692 0.91 CYP1A2 (0.50) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8717173 0.88 CYP1A2 (0.49) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8947574 0.88 CYP1A2 (0.49) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8720056 0.85 CYP1A2 (0.47) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8719939 0.82 CYP1A2 (0.44) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8719543 0.82 CYP1A2 (0.44) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL8721817 0.81 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL27309404 0.80 CYP1A2 (0.59) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL7817305 0.80 CYP1A2 (0.59) CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2
SCHEMBL23496889 0.79 CTSS (0.47) CTSKCTSSCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5763604-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
US-5677448-A CHEMICAL INTERMEDIATES FOR MAKING ANTAGONIST OF THROMBIN, TREATING THROMBOSIS, STROKE, INFLAMMATION, ARTERIOSCLEROSIS, CARDIOVASCULAR DISORDERS HOFFMANN-LA ROCHE INC. (US) 1997-10-14 US disclosed
US-5578594-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1996-11-26 US disclosed
US-5405854-A Anticoagulants HOFFMANN-LA ROCHE INC. (US) 1995-04-11 US disclosed