Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | POLG | P54098 | 2/20 | 0.66 |
| ▸ | POLA1 | P09884 | 1/20 | 0.66 |
| ▸ | HPRT1 | P00492 | 9/20 | 0.60 |
| ▸ | PNP | P00491 | 8/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | EDNRA | P25101 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | HBB | P68871 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316171 | 0.93 | POLB (0.67) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL17622521 | 0.91 | POLB (0.64) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL19470300 | 0.90 | PNP (0.58) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL19470231 | 0.90 | POLB (0.57) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL8717524 | 0.90 | POLB (0.81) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL2734888 | 0.87 | POLB (0.73) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL17617639 | 0.86 | POLB (0.67) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL24792586 | 0.85 | POLB (0.63) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL17617613 | 0.85 | POLB (0.60) | POLBPOLGPOLA1HPRT1PNP | |
| SCHEMBL17617664 | 0.85 | POLB (0.62) | POLBPOLGPOLA1HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854228-A | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1998-12-29 | — | — | US | disclosed |
| US-5650510-A | VIRICIDES OR ANTITUMOR AGENTS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-07-22 | — | — | US | disclosed |
| EP-0269947-B2 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1996-10-16 | — | — | EP | disclosed |
| EP-0269947-A1 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1988-06-08 | — | — | EP | disclosed |