Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.84 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.84 |
| ▸ | ADCY5 | O95622 | 4/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.56 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | POLA1 | P09884 | 1/20 | 0.54 |
| ▸ | POLG | P54098 | 1/20 | 0.54 |
| ▸ | FAP | Q12884 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352757 | 0.96 | FGFR1 (0.86) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL49373 | 0.91 | FGFR1 (1.00) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL29365535 | 0.91 | FGFR1 (1.00) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL29115272 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL28765885 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL3643715 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL439995 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL28571494 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL3639260 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 | |
| Adefovir SCHEMBL29064626 | 0.90 | FGFR1 (0.97) | FGFR1SLC22A6ADCY5ADORA2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854228-A | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1998-12-29 | — | — | US | disclosed |
| US-5650510-A | VIRICIDES OR ANTITUMOR AGENTS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-07-22 | — | — | US | disclosed |
| EP-0269947-B2 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1996-10-16 | — | — | EP | disclosed |
| US-4808716-A | VIRICIDES OR CHEMICAL INTERMEDIATES | CESKOSLOVENSKA AKADEMIC VED (CS) | 1989-02-28 | — | — | US | disclosed |
| EP-0269947-A1 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1988-06-08 | — | — | EP | disclosed |
| EP-0206459-A2 | 9-(Phosphonylmethoxyalkyl) adenines, method for their preparation and their use | Ceskoslovenska akademie ved (CS) | 1986-12-30 | — | — | EP | disclosed |