Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adefovir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | POLA1 | P09884 | 1/20 | 0.62 |
| ▸ | POLG | P54098 | 1/20 | 0.62 |
| ▸ | FAP | Q12884 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | NSD3 | Q9BZ95 | 5/20 | 0.54 |
| ▸ | NSD2 | O96028 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adefovir SCHEMBL49373 | 1.00 | FGFR1 (1.00) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL28511793 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL28571494 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL29115272 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL3639260 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL439995 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL28765885 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL3643715 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL29064626 | 0.99 | FGFR1 (0.97) | FGFR1SLC22A6ABCB11POLA1POLG | |
| Adefovir SCHEMBL439994 | 0.95 | FGFR1 (0.91) | FGFR1SLC22A6ABCB11POLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 571 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122042499-A | Sealing pressure measuring hole device capable of replacing sensor cavity and gallery monitoring method | 中国水利水电科学研究院 | 2026-05-15 | — | — | CN | claimed |
| US-20260131049-A1 | RESIN COMPOSITION, MEDICAL MATERIAL, AND METHOD FOR PRODUCING RESIN COMPOSITION | NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP) | 2026-05-14 | — | — | US | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-12584991-B2 | UWB-based in-vehicle 3D localization of mobile devices | GM Global Technology Operations LLC (US) | 2026-03-24 | — | — | US | claimed |
| US-12497435-B2 | Multimerization of IL-15/IL-15R-alpha-fc complexes to enhance immunotherapy | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2025-12-16 | — | — | US | claimed |
| US-12447445-B2 | Porous separation membrane | TORAY INDUSTRIES, INC. (JP) | 2025-10-21 | — | — | US | claimed |
| US-12331302-B2 | Fungal autoinducible expression system | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-06-17 | — | — | US | claimed |
| CN-114372343-B | Photovoltaic array local shadow detection and mismatch degree estimation method | 河海大学常州校区 | 2025-06-03 | — | — | CN | claimed |
| WO-2025109441-A1 | METHOD OF DETERMINING THE STATE OF POWER OF A TRACTION BATTERY OF AN ELECTRIC VEHICLE, CORRESPONDING SYSTEM, VEHICLE AND COMPUTER PROGRAM PRODUCT | MASERATI S.P.A. (IT) | 2025-05-30 | — | — | WO | claimed |
| CN-120011986-A | Electricity larceny behavior identification method based on terminal data tide characteristics | 国网浙江省电力有限公司绍兴供电公司 | 2025-05-16 | — | — | CN | claimed |
| EP-3903855-B1 | BLOOD PURIFICATION DEVICE AND EXTRACORPOREAL BLOOD CIRCULATION SYSTEM PROVIDED WITH BLOOD COMPONENT ADJUSTER | ASAHI KASEI MEDICAL CO LTD (JP) | 2022-10-26 | — | — | EP | claimed |
| CN-114720988-A | Single hydrophone low-frequency broadband matching field distance measuring method based on modal phase | 西北工业大学 | 2022-07-08 | — | — | CN | claimed |
| CN-112698270-B | Design method of unidirectional acoustic array with broadband constant main beam | 中国铁路设计集团有限公司 | 2022-06-24 | — | — | CN | claimed |
| CN-114519752-A | High-resolution fast-calculation passive ultrasonic imaging method and system | 西安交通大学 | 2022-05-20 | — | — | CN | claimed |
| CN-114447971-A | Super capacitor and battery hybrid energy storage device with general applicability | 力容新能源技术（天津）有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-114372343-A | Photovoltaic array local shadow detection and mismatch degree estimation method | 河海大学常州校区 | 2022-04-19 | — | — | CN | claimed |
| US-20220106375-A1 | MULTIMERIZATION OF IL-15/IL-15R-ALPHA-FC COMPLEXES TO ENHANCE IMMUNOTHERAPY | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2022-04-07 | — | — | US | claimed |
| CN-113028493-B | Online matching and adjusting method for heating load and heat demand of regional heating system | 西安交通大学 | 2022-04-05 | — | — | CN | claimed |
| CN-112890790-B | Wearable noninvasive dynamic blood pressure tracking and monitoring method | 浙江大学 | 2022-03-15 | — | — | CN | claimed |
| US-20220062522-A1 | EXTRACORPOREAL BLOOD CIRCULATION SYSTEM PROVIDED WITH BLOOD PURIFICATION DEVICE AND BLOOD COMPONENT ADJUSTER | ASAHI KASEI MEDICAL CO., LTD. (JP) | 2022-03-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12584991-B2 | UWB-based in-vehicle 3D localization of mobile devices | KIF18B, KIF15, KIF18A | FGFR1 2084/4885SLC22A6 3126/4885ABCB11 3888/4885 |
| US-20260131049-A1 | RESIN COMPOSITION, MEDICAL MATERIAL, AND METHOD FOR PRODUCING RESIN COMPOSITION | FGB, ARGLU1, GLMN | FGFR1 381/4885SLC22A6 4201/4885ABCB11 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.