Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 2/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27508813 | 0.84 | DGAT1 (0.33) | KDM1ACYP4F2CYP4A11 | |
| SCHEMBL15423563 | 0.82 | MAPK1 (0.34) | MAPK1MEN1KMT2AGRM6GRM2 | |
| SCHEMBL14857889 | 0.81 | BTK (0.32) | KDM1A | |
| SCHEMBL4206402 | 0.81 | BTK (0.32) | KDM1A | |
| SCHEMBL12987712 | 0.81 | BTK (0.32) | KDM1A | |
| SCHEMBL12987233 | 0.80 | BTK (0.31) | KDM1A | |
| SCHEMBL4197528 | 0.80 | BTK (0.31) | KDM1A | |
| SCHEMBL2557566 | 0.80 | BTK (0.31) | KDM1A | |
| SCHEMBL2561559 | 0.80 | BTK (0.31) | KDM1A | |
| SCHEMBL4206000 | 0.80 | BTK (0.31) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105111155-B | A kind of synthetic method of 4,7- diaza spiro [2.5] octane -7- t-butyl formate | 武汉工程大学 | 2018-12-14 | — | — | CN | claimed |
| CN-105111155-A | Synthesis method of tert-butyl 4,7-diazaspiro[2.5]octyl-7-formate | WUHAN INST TECHNOLOGY | 2015-12-02 | — | — | CN | claimed |
| CN-105111155-B | A kind of synthetic method of 4,7- diaza spiro [2.5] octane -7- t-butyl formate | 武汉工程大学 | 2018-12-14 | — | — | CN | disclosed |
| CN-107108634-A | Imidazopyridazine derivatives as PI3K beta inhibitors | 詹森药业有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105111155-A | Synthesis method of tert-butyl 4,7-diazaspiro[2.5]octyl-7-formate | WUHAN INST TECHNOLOGY | 2015-12-02 | — | — | CN | disclosed |
| CN-103201276-B | Indole derivatives | RICHTER GEDEON NYRT | 2015-02-25 | — | — | CN | disclosed |
| CN-104230900-A | Antiviral compounds | GILEAD SCIENCES INC | 2014-12-24 | — | — | CN | disclosed |
| CN-104211713-A | Antiviral compounds | GILEAD SCIENCES INC | 2014-12-17 | — | — | CN | disclosed |
| CN-104211689-A | Antiviral compounds | GILEAD SCIENCES INC | 2014-12-17 | — | — | CN | disclosed |
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| CN-104016971-A | Antiviral compounds | GILEAD SCIENCES INC | 2014-09-03 | — | — | CN | disclosed |
| EP-2106396-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | AstraZeneca AB (SE) | 2009-10-07 | — | — | EP | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
| CN-101421256-A | Thiadiazolidinone inhibitors of ptpase | NOVARTIS AG (CH) | 2009-04-29 | — | — | CN | disclosed |
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
| CN-1036193-C | Preparation of a sprio compound | DAIICHI SEIYAKU CO (JP) | 1997-10-22 | — | — | CN | disclosed |
| CN-1143647-A | Dipeptides which promote release of growth hormone | PFIZER (US) | 1997-02-26 | — | — | CN | disclosed |
| CN-1028102-C | Preparation of spiro compounds | DAIICHI SEIYAKU CO (JP) | 1995-04-05 | — | — | CN | disclosed |
| CN-1100095-A | Preparation of a sprio compound | DAIICHI SEIYAKU CO (JP) | 1995-03-15 | — | — | CN | disclosed |
| CN-1040790-A | Preparation of spiro compounds | DAIICHI SEIYAKU CO (JP) | 1990-03-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | KDM1A 1835/4885MAPK1 849/4885MEN1 2567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.