Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11435499 | 0.85 | CYP1A2 (0.50) | ALDH1A1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL2929137 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11440523 | 0.82 | HTT (0.55) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11638101 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11525238 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11438226 | 0.81 | CA12 (0.52) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11441458 | 0.81 | HTT (0.56) | ALDH1A1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL14211024 | 0.80 | KMT2A (0.58) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11521917 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1RAB9AMAPT | |
| SCHEMBL11184067 | 0.80 | GAA (0.54) | ALDH1A1KMT2AMEN1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773470-A | TREATING RHEUMATIC DISEASES, AUTOIMMUNE DISEASES AND REJECTION REACTIONS DUE TO ORGAN TRANSPLANTING | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| US-5747664-A | N-Phenyl-2-cyano-3-hydroxycrotonamide derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0538783-B1 | N-phenyl-2-cyano-3-hydroxycrotonic acid amid derivatives and their use as medicaments having immunomodulating properties | HOECHST AG (DE) | 1995-09-27 | — | — | EP | disclosed |
| EP-0538783-A1 | N-phenyl-2-cyano-3-hydroxycrotonic acid amid derivatives and their use as medicaments having immunomodulating properties | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-28 | — | — | EP | disclosed |