Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718146 | 1.00 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL13524429 | 0.87 | DHODH (0.62) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL12117514 | 0.84 | ALDH1A1 (0.50) | DHODHALDH1A1BLMTHRBGAA | |
| SCHEMBL8714895 | 0.83 | DHODH (0.69) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL8714900 | 0.83 | DHODH (0.69) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL9206813 | 0.83 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL8716083 | 0.83 | DHODH (0.59) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL8716086 | 0.83 | DHODH (0.59) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL8715471 | 0.83 | DHODH (0.58) | DHODHALDH1A1MEN1KMT2ABLM | |
| SCHEMBL13530070 | 0.82 | DHODH (0.57) | DHODHALDH1A1MEN1KMT2ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538783-B1 | N-phenyl-2-cyano-3-hydroxycrotonic acid amid derivatives and their use as medicaments having immunomodulating properties | HOECHST AG (DE) | 1995-09-27 | — | — | EP | claimed |
| US-5773470-A | TREATING RHEUMATIC DISEASES, AUTOIMMUNE DISEASES AND REJECTION REACTIONS DUE TO ORGAN TRANSPLANTING | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| US-5747664-A | N-Phenyl-2-cyano-3-hydroxycrotonamide derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-05 | — | — | US | disclosed |