Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718213 | 0.92 | HTR2C (0.47) | HTR2CHDAC4HSD11B1DDB1CRBN | |
| SCHEMBL8718206 | 0.75 | TRPA1 (0.50) | MGLL | |
| SCHEMBL29497332 | 0.75 | HTR2C (0.61) | HTR2CHDAC4HSD11B1DDB1CRBN | |
| SCHEMBL29871435 | 0.74 | HTR2C (0.64) | HTR2CDDB1CRBN | |
| SCHEMBL1128179 | 0.74 | HTR2C (0.64) | HTR2CDDB1CRBN | |
| SCHEMBL8130416 | 0.74 | HTR2C (0.64) | HTR2CDDB1CRBN | |
| SCHEMBL1515219 | 0.72 | HTR2C (0.67) | HTR2CHSD11B1DDB1CRBN | |
| SCHEMBL43079 | 0.72 | HTR2C (0.67) | HTR2CHSD11B1DDB1CRBN | |
| SCHEMBL31469392 | 0.72 | HTR2C (0.67) | HTR2CHSD11B1DDB1CRBN | |
| SCHEMBL1225741 | 0.71 | HTR2C (0.72) | HTR2CDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880529-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030056-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |