Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18822924 | 0.98 | DPP4 (0.34) | DPP4SLC6A4SLC6A3 | |
| SCHEMBL8718241 | 0.88 | SLC6A4 (0.37) | DPP4SLC6A4SLC6A3 | |
| SCHEMBL18710256 | 0.86 | DPP4 (0.35) | DPP4SLC6A4SLC6A3 | |
| SCHEMBL17112816 | 0.84 | SLC6A4 (0.37) | DPP4SLC6A4SLC6A3 | |
| SCHEMBL18466621 | 0.80 | — | — | |
| SCHEMBL18710397 | 0.78 | DPP4 (0.36) | DPP4SLC6A4SLC6A3 | |
| SCHEMBL19498155 | 0.78 | BACE1 (0.30) | — | |
| SCHEMBL22703955 | 0.77 | DPP4 (0.33) | DPP4 | |
| SCHEMBL24921209 | 0.77 | SIGMAR1 (0.33) | DPP4 | |
| SCHEMBL12840852 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880529-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030056-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |