Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607676 | 1.00 | LTA4H (0.66) | LTA4HHRH3ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6606769 | 0.83 | LTA4H (0.50) | LTA4HALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL3805981 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL3450537 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL29253444 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL3450541 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14924490 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL18085065 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL6189046 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL18085066 | 0.82 | LTA4H (0.61) | LTA4HHRH3ALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840721-A | INCREASE SENSITIVITY OF MULTIDRUG RESISTANT TUMOR CELLS TO ANTICANCER AGENTS | ONTOGEN CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |