SCHEMBL8718920

SCHEMBL8718920

Cc1ccc(C(=O)C(O)[C@H]2O[C@](O)(Cl)C[C@@]2(O)C(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.33
CES2 O00748 2/20 0.33
CES1 P23141 2/20 0.33
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CHRM2 P08172 1/20 0.31
ADRA2B P18089 1/20 0.31
DRD3 P35462 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
PKM P14618 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
SLC6A3 Q01959 4/20 0.30
SLC6A2 P23975 3/20 0.30
SLC6A4 P31645 3/20 0.30
LMNA P02545 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2471234 1.00 HPGD (0.33) HPGDCES2CES1NPC1RAB9A
SCHEMBL6142770 1.00 HPGD (0.33) HPGDCES2CES1NPC1RAB9A
SCHEMBL1799677 0.90 HPGD (0.33) HPGDCES2CES1NPC1RAB9A
SCHEMBL2476284 0.90 GSK3B (0.32) CES2CES1LMNAALDH1A1GAA
SCHEMBL2476289 0.90 GSK3B (0.32) CES2CES1LMNAALDH1A1GAA
SCHEMBL8112010 0.79 KMT2A (0.33) HPGDCES2CES1L3MBTL1LMNA
SCHEMBL8112015 0.79 KMT2A (0.33) HPGDCES2CES1L3MBTL1LMNA
SCHEMBL9614440 0.78 HPGD (0.33) HPGDCES2CES1CHRM2ADRA2B
SCHEMBL11104413 0.78 HPGD (0.33) HPGDCES2CES1CHRM2ADRA2B
SCHEMBL16446965 0.78 HPGD (0.33) HPGDCES2CES1CHRM2ADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821357-A REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST TWO MOLAR EQUIVALENTS OF METAL DERIVATIVE OF NUCLEOBASE IN LOW FREEZING INERT SOLVENT ELI LILLY AND COMPANY (US) 1998-10-13 US disclosed
US-5648473-A GLYCOSYLATION IN SOLVENT ELI LILLY AND COMPANY (US) 1997-07-15 US disclosed
US-5606048-A REACTING A CONCENTRATED ALPHA- OR BETA-ANOMER ENRICHED 1-DEOXY-2,2-DIFLUOROCARBOHYDRATE OR 2-DEOXY-2-FLUOROCARBOHYDRATE WITH A MOLAR EQUIVALENT OF A NUCLEOBASE DERIVATIVE IN A HIGH BOILING INERT SOLVENT ELI LILLY AND COMPANY (US) 1997-02-25 US disclosed
US-5594124-A REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST THREE MOLAR EQUIVALENTS OF PROTECTED NUCLEOBASE IN LOW FREEZING INERT SOLVENT ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
US-5426183-A Reacting 2'-deoxy-2(2)-(di)fluorocarbohydrate witha nucleobase in an inert solvent ELI LILLY AND COMPANY (US) 1995-06-20 US disclosed
US-5401838-A Reaction of sulfonate furanose with nucleobase ELI LILLY AND COMPANY (US) 1995-03-28 US disclosed
US-5371210-A Reacting alpha anomer enriched 2-deoxy-2,2-difluorocarbo-hydrate with nucleobase ELI LILLY AND COMPANY (US) 1994-12-06 US disclosed